MOLECULAR INSIGHT

TREG SIGNATURE
TregSign heatmap

We have developed an original Treg Molecular Signature (TregSign kit) which allows, in a single assay, a complete transcriptomic study of Tregs.

The signature allows us to determine the impact of a molecule on Tregs and their microenvironment

The signature is based on the expression of 80 genes related to natural Tregs, induced Tregs and their surroundings. 8 gene clusters were established to better assess Treg biology :

Phenotype
Suppressive function
Expansion
Induction
Adhesion
Activation state
Migration
Infiltration
Plasticity

Preclinical Potential applications

In vitro and in vivo 

  • Lead identification & screening
  • Safety & Immunotoxicity
  • Assessment of new therapeutic candidates regarding Treg response
  • Proof of Concept 

Clinical potential applications

Diagnostics & Therapeutics

  • Patient immuno-monitoring
  • Patient stratification for better treatment choice
  • Diagnostic and prognostic value

CELLULAR INSIGHT

IMMUNOTORING AND CHARACTERIZATION

PBMC/Treg Supression Assay

We offer a wide range of methods to comprehensively assess the efficacy and safety of your compound of interest on Treg Biology. Immunomonitoring and Immunophenotyping of Tregs by :

Suppressive Function Assays
Recruitment Analysis
Secretion Profile
Cell Death & Viability Assay
Tumour Infiltration Analysis

ANIMAL INSIGHT

PRE-CLINICAL CUSTOM-MADE IN VIVO CANCER MODELS

In vivo assessment of a compound efficacy and safety can be carried out on a human cancer model designed for you (Syngeneic, PDX-Like models…).

PDX-Like model: Humanized SCID mice allow a complete monitoring of disease advancement, organ infiltration, toxicity etc.

Tumour size and Treg infiltration monitoring (in vivo PDX-Like cancer model)

REFERENCES

Bibliography of Immune insighT and its founding members:

IST: Immune insighT

Treg Signature (TregSign Kit) POC

    Fresh PBMCs

     Frozen PBMCs

     Patient serum

     Tumor tissue sample

     Other tissue sample

Clinical trial immunomonitoring

Humanized PDX-Like model POC

 Review 

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