MOLECULAR INSIGHT

TREG SIGNATURE
TregSign heatmap

We have developed an original Treg Molecular Signature (TregSign kit) which allows, in a single assay, a complete transcriptomic study of Tregs.

The signature allows us to determine the impact of a molecule on Tregs and their microenvironment

The signature is based on the expression of around 100 genes associated with both natural Treg and induced Tregs. 8 clusters were established to better assess Treg biology :

Phenotype
Suppressive function
Expansion
Induction
Adhesion
Activation state
Migration
Infiltration
Plasticity

Potential clinical applications: Evaluation of compounds on Tregs/PBMCs Patient immuno-monitoring – Strong diagnostic and prognostic value – Improvement of patient stratification according to Treg profile for better treatment choice

CELLULAR INSIGHT

IMMUNOTORING AND CHARACTERIZATION

PBMC/Treg Supression Assay

We offer a wide range of methods to comprehensively assess the efficacy and safety of your compound of interest on Treg Biology. Immunomonitoring and Immunophenotyping of Tregs by :

Suppressive Function Assays
Recruitment Analysis
Secretion Profile
Cell Death & Viability Assay
Tumour Infiltration Analysis

ANIMAL INSIGHT

PRE-CLINICAL CUSTOM-MADE IN VIVO CANCER MODELS

In vivo assessment of a compound efficacy and safety can be carried out on a human cancer model designed for you (Syngeneic, PDX-Like models…).

PDX-Like model: Humanized SCID mice allow a complete monitoring of disease advancement, organ infiltration, toxicity etc.

Tumour size and Treg infiltration monitoring (in vivo PDX-Like cancer model)
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