MOLECULAR INSIGHT
We have developed an original Treg Molecular Signature (TregSign kit) which allows, in a single assay, a complete transcriptomic study of Tregs.
The signature allows us to determine the impact of a molecule on Tregs and their microenvironment
The signature is based on the expression of around 100 genes associated with both natural Treg and induced Tregs. 8 clusters were established to better assess Treg biology :
Phenotype
Suppressive function
Expansion
Induction
Adhesion
Activation state
Migration
Infiltration
Plasticity
Potential clinical applications: Evaluation of compounds on Tregs/PBMCs Patient immuno-monitoring – Strong diagnostic and prognostic value – Improvement of patient stratification according to Treg profile for better treatment choice
CELLULAR INSIGHT
PBMC/Treg Supression Assay
We offer a wide range of methods to comprehensively assess the efficacy and safety of your compound of interest on Treg Biology. Immunomonitoring and Immunophenotyping of Tregs by :
Suppressive Function Assays
Recruitment Analysis
Secretion Profile
Cell Death & Viability Assay
Tumour Infiltration Analysis
ANIMAL INSIGHT
In vivo assessment of a compound efficacy and safety can be carried out on a human cancer model designed for you (Syngeneic, PDX-Like models…).
PDX-Like model: Humanized SCID mice allow a complete monitoring of disease advancement, organ infiltration, toxicity etc.
REFERENCES
Bibliography of Immune insighT and its founding members:
IST: Immune insighT
Humanized PDX-Like model POC
Clinical trial immunomonitoring
TregSign Kit POC
Review